To comply with data protection requirements when using blockchain in the storage of data, businesses must consider various challenges of significance. Initially, businesses must recognize that the security and transparency in blockchain, arising from the immutable structure of decentralized networks, may conflict with data protection laws such as the GDPR that allows for deletion or correction of personal data. Businesses may therefore wish to craft solutions that allow them to comply with data protection laws, such as storing only non-personal data on-chain or using some off-chain storage with cryptographic links to rely on the blockchain. Encryption is a key step to protect personal data and reduce risks related to re-identification attacks. Furthermore, businesses must understand the roles and responsibilities of miners and blockchain operators to ensure these parties meet their obligations under data protection regulations. Understanding the global regulatory environment is critical because business networks are often decentralized and border instances. Data protection laws may differ from jurisdiction to jurisdiction. Businesses must develop a response related to their blockchain initiative. Principles related to privacy by design must be fully incorporated, to reinforce transparency and further demonstrate their support for data subject rights related to access and rectification.